i have the same problem with this post: http://www.picotech.com/support/topic12043.html
my PICO (3 years old) just suddenly stops.
windows recognizes the hardware when plug in but PICO soft does not find it (just 1 click sound when i ran the soft).
tried it on different pc's (xp sp2, xp sp3, win7)
is there anything i can do to revive my PICO? or is it just it's end of time?
as Martyn suggested on the above post, what should i check or do with my .Net version?
maybe it is just a corrupted firmware or eeprom dumps?
Which Picoscope model do you have and which version of the software are you using. Help->About in the software will give the required information to cut and paste here.