I have had Pico Scope 2205 for about a year and have been rather satisfied - excellent solution for my occasional use.
I am running the software on an Intel MAC OS X 10.5 - VMWare - Win NT -setup. All fine.
Now after some months of no-usage I needed the scope again, but had no success.
Every time PicoScope 6.4.92 scans for connected scope, the USB connection breaks up. I can observe that happening from WIndows Hardware Manager: upon plugging the scope into an USB port I can see it appearing there - when starting PicoScope I hear an USB disconnect sound and can see the scope getting de-listed from the USB devices list. The same happens when asking PicoScope to refresh the list of available scopes.
I have tried this with XP and Vista as well. I also have uninstalled *all* pico SW and drivers and then done a clean install. Also tried rebooting after a clean install. Systematically the same result.