I have tried and no, r6_5_64 does not solve the problem for me.
This is what I did after having used the Picoscope:
-Stop the software Picoscope6
-Send PC to hibernation
-Cut the Picoscope power
-Power up Picoscope again
-Wake up PC
=> Message stating "no hardware found, want a demo device?"
Stopping and restarting PicoScope6 doesn't solve the problem but disconnecting and reconnecting the USB cable does.
Note: While Picoscope6 can't find the Picoscope device, Windows lists it as functional and e.g. Microsoft's USBView enumerates the Picoscope hardware ok.
I'm using Win XP SP3 on an Acer AspireOne in this case.