I have a Picoscope 4224 running with Windows Vista64 and haven't used the 'scope for a few months (was running with version 188.8.131.52) so have only now upgraded to the latest version 184.108.40.206 , but it's freezing (with "Not responding") as soon as you do anything after it's started up.
Even just clicking Tools/Preferences/OK causes it to freeze. Trying to change any of the settings on the main screen, or starting a capture also cause it to freeze.
Help/About works and it shows that the 4224 has been detected OK.
I completely uninstalled the old version before installing 220.127.116.11.
I've now reverted back to version 18.104.22.168 and it's working OK.
Any ideas on how to get 22.214.171.124 working with Vista64?