There appears to be a corrupt file on your system when the upgrade was installed. You should be able to simply run the install program and instead of uninstalling and reinstalling select the repair option. This will ensure that the installer completely replaces all the files that the program uses. Occasionally when you uninstall/reinstall the programs not all the files are correctly deleted/replaced.
If the repair option does not work then I would recommend a fresh reinstall to ensure that the corrupted file is deleted.
First off with the PicoScope program not running and the PicoScope unit unplugged follow the below steps.
To access the files that I mention below go to the following folders in Windows Explorer and delete them. These folders may be hidden so you may have to go to your folder options under tools and select to show hidden files and folders.
To delete the programs files navigate to and delete the following folder:
C:\Program Files\Pico Technology\PicoScope6
To delete the settings file delete the following folder.
For Vista operating system:
C:\Users\<insert you login user name here>\AppData\Local\Pico Technology
For XP operating system:
C:\Documents and Settings\<insert you login user name here>\Local Settings\Application Data\Pico Technology
Now rerun the 6.1.0 installation program to replace the files. Then reconnect the PicoScope unit and run the PicoScope 6 program. If the program does crash still let us know if it will run without the PicoScope unit attached to the computer and if it does after the PicoScope program is running try connecting the PicoScope unit and going to File and Connect Device and see if the program can successfully open the unit this way.
Let me know how you get along and if following these steps provide you with a solution to your problem.
Crag Technologies, Inc