Ok, I just tried connecting the Pico ADC-16 via the USB-Serial Adapter on COM 3, which I have my Weather Station connected to that works.
No response from the ADC-16 at all. ~ Device not found etc.
I also tried to connect my Weather Station to COM 7 of the PCI Serial Card. The Weather Station comes with a serial (15 way) to RJ11 socket adapter, they supply a loopback connector to go into the RJ11 socket. The Weather station software on my PC found COM7, however, when the loopback is replaced with the connector to the Weather Station it can't see it? I also tried to change the baud speed from 9600 to 2400, 2400 is what the Weather Station is normally connected at, this made no difference.
When I reboot the PC it doesn't "find new hardware" everytime, nothing to suggest it's not installed correctly, which I would expect if the drivers for the PCI Card were not installed correctly.
Again, I don't think this is a Pico issue, but thought I'd run it across this forum.