I've noticed an odd difference between channels - it is NOT an issue for me, unless it is an indication of something else I've not yet discovered. Nevertheless, I'm hoping someone may be able to offer an explanation.
I'm using a 2205 MSO in analog mode only. Picoscope version 18.104.22.1688
While 'zeroing' the probes I've noticed different behaviour between ChA and ChB despite (TTBOMK) them being set the same, i.e. Probe x10, Resolution 8 bits Input Range of +/- 5V. Both probe tips are connected to their own ground clip.
Chan A appears to be much more 'noisy' than Chan B - not in the peak2peak value of the noise (both channels ~50mV which I believe is normal and due to digitization) but in the 'number of transitions' (I'm not sure what to call this, frequency seems wrong). For example at 1uS/div Chan A has ~200 mini spikes while Chan B has 5. I've tried physically swapping the probes, Chan A remains more noisy. I've also readjusted the frequency compensation of both probes.
I've attached a pdf of a couple of traces (with both axis scaled to x10).