I've tried using the current release 220.127.116.11 and the 18.104.22.168 and neither work. You get the 'scope working for a few seconds, but by the time you've configured PicoScope to the settings needed for the job it hangs up. If you do manage to get the 'scope set up in time and try to save an image then it'll definitely hang up. I'm not completely convinced that my issues are VM related, but I've no non-VM machines to test against. If the PicoScope software fails this badly under "normal" Windows operation then you've very serious issues if you can't resolve the problems.
These issues have been around for a long time now, and there seems to be little or no progress. I've also raised issues with the Linux drivers for PicoScope and similarly there seems to be no progress. Issues with VMs were raised over a year ago, as were Linux driver issues.
When I bought my PicoScope my view was the a company which was based in the UK and supported Linux meant that I was onto a good thing. I was wrong, I'm now looking to change to Agilent and National Instruments, as although the base equipment is more expensive, it'll work.
Sorry that my posting has become a bit of a rant, but since I purchased my PicoScope it's hardly been used, and is quite an expensive blue bookend.