Thanks Hitesh, You're correct, explicitly disabling works, I'm now able to acquire with a 2ns interval by calling: Call ps3000aSetChannel(handle, 0, 1, 1, RangeA, 0) ' Ch A: enabled, DC Coupled, RangeA, 0.0V offset Call ps3000aSetChannel(handle, 1, 1, 1, RangeB, 0) ' Ch B: enabled, DC Coupled, Range...